Snegirev D.V., Mannapova R.T., Mannapov A.G.

Mechanisms of ecological restoration of the immune defense of Oreochromis niloticus by propolis with sensitizers against the background of the development of candidiasis

In the last decade, with aquarium maintenance, pathogenic Candida albicans species are isolated from fish, causing up to 95-100% mortality. This paper describes the mechanisms of natural immune protection of Oreochromis niloticus, against the background of the development of candidiasis of the digestive tube under the influence of an environmentally friendly biologically active beekeeping product (BAPP) – propolis in combination with sensitizers. It was found that the use of propolis (group 3), propolis in combination with methylene blue (group 4), proflavin acetate (group 5), zinc phthalocyanine (group 6) contributed to an increase in lysozyme activity of blood serum, compared with the data of fish of group 2 (patients, untreated) by a maximum of 14.3; 19.13; 5.69 and 5.43 times, the bactericidal activity of blood serum – 4.1; 4.78; 2.27 and 2.25 times. This indicates the high efficiency, environmental friendliness of the use of propolis in combination with methylene blue for the prevention and therapy of developed candidiasis.

Keywords: CANDIDAMYCOSIS, DIGESTIVE TRACT, CANDIDA ALBICANS, OREOCHROMIS NILOTICUS, PROPOLIS, LYSOZYME AND BACTERICIDAL ACTIVITY OF BLOOD SERUM